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This bidirectional NO interaction gives this compound an adaptability in biological environments that single-pathway peptides lack, and may contribute to its consistency of effect across diverse tissue types and experimental conditions

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However, this cannot be the full explanation, as pyridostigmine is not able to fully reverse the hyposomatotropinism of obesity, even when combined with GHRH and the GH secretagogue GHRP-6 (515)

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